TYRPHOSTIN AG 1296
Tyrphostin AG 1296
CAS: 146535-11-7
Molecular Formula: C16H14N2O2
TYRPHOSTIN AG 1296 - Names and Identifiers
TYRPHOSTIN AG 1296 - Physico-chemical Properties
| Molecular Formula | C16H14N2O2 |
| Molar Mass | 266.29 |
| Density | 1.192±0.06 g/cm3(Predicted) |
| Boling Point | 420.2±40.0 °C(Predicted) |
| Solubility | Soluble in DMSO. |
| Appearance | White solid |
| Color | Yellow |
| pKa | 0.48±0.30(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Sensitive | Light Sensitive |
| In vitro study | AG1296 acts on Swiss 3T3 cells and porcine aortic endothelial cells to selectively inhibit PDGF receptor kinase and PDGF-dependent DNA synthesis, with 50% inhibition concentrations below 5 and 1 μm, respectively. AG1296 acted on Swiss 3T3 cells and inhibited FGFR and c-Kit with IC50 of 12.3 μm and 1.8 μm, respectively. AG1296 acts on porcine aortic endothelial cells and effectively inhibits human PDGF-α and-β receptor signaling pathways, but has no effect on autophosphorylation of VEGFR KDR or VEGF-induced DNA synthesis. AG1296 treatment reversed the transformation phenotype of sis-transfected NIH 3T3 cells, but had no effect on src-transformed NIH 3T3 cells. AG1296 is a competitive inhibitor of ATP. AG1296 interferes with PDGF binding or PDGF receptor dimerization and abrogates PDGF receptor autophosphorylation. Thus, AG1296 is a pure inhibitor of the catalytic activity of receptor tyrosine kinases. |
TYRPHOSTIN AG 1296 - Risk and Safety
| WGK Germany | 3 |
TYRPHOSTIN AG 1296 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.755 ml | 18.777 ml | 37.553 ml |
| 5 mM | 0.751 ml | 3.755 ml | 7.511 ml |
| 10 mM | 0.376 ml | 1.878 ml | 3.755 ml |
| 5 mM | 0.075 ml | 0.376 ml | 0.751 ml |
Last Update：2024-01-02 23:10:35
TYRPHOSTIN AG 1296 - Reference Information
| biological activity | Tyrphostin AG 1296 is a PDGFR inhibitor with IC50 of 0.3-0.5 μm, there was no inhibitory activity against EGFR. Tyrphostin AG 1296 is a PDGFR inhibitor with an IC50 of 0.3-0.5 μm and no inhibitory activity against EGFR. Tyrphostin AG1296 inhibited FGFR and c-Kit in Swiss 3T3 cells with IC50 values of 12.3 μm and 1.8 μm. Tyrphostin AG1296 can induce severe apoptosis in A375R cells. |
| characteristics | AG1296 acts on normal and sis-transformed mouse fibroblasts and porcine aortic endothelial cells expressing human PDGF receptors, more potent and more specific than previously reported Tyrphostin-type inhibitors. |
| Target | Value |
| PDGFR | 0.3 μM-0.5 μM |
| c-Kit (Swiss 3T3) | 1.8 μM |
| FGFR (Swiss 3T3) | 12.3 μM |
Last Update：2024-04-09 21:32:10
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CAS: 146535-11-7
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CAS: 146535-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: AG 1296 Visit Supplier Webpage Request for quotationCAS: 146535-11-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Tyrphostin AG 1296 Request for quotationCAS: 146535-11-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Tyrphostin AG 1296 Visit Supplier Webpage Request for quotationCAS: 146535-11-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AG1296 Visit Supplier Webpage Request for quotationCAS: 146535-11-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Tyrphostin AG 1296 Visit Supplier Webpage Request for quotation
CAS: 146535-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 146535-11-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
TYRPHOSTIN AG 1296
Indium nitrate
BIOTIN COATED MICROSPHERES YG
fthalide (jmaf)
FNA Medium (Fluorescein Denitrification Agar)
FEMA No. 3346
Indium nitrate
BIOTIN COATED MICROSPHERES YG
fthalide (jmaf)
FNA Medium (Fluorescein Denitrification Agar)
FEMA No. 3346